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Research peptide
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🔬 R3 — Research Peptide
R3 (LY 3437943) is an investigational research peptide and a triple-agonist that activates the GLP-1, GIP, and glucagon (GCG) receptors. It is studied for its potential effects on weight management, metabolic regulation, and energy balance in preclinical and clinical research settings.
Research Focus & Mechanism
• GLP-1 receptor activation: Investigated for improving glycemic control and regulating appetite
• GIP receptor activation: Studied for enhancing insulin secretion and supporting glucose metabolism
• Glucagon receptor activation: Explored for increasing energy expenditure, lipolysis, and potential effects on liver fat metabolism
• Slows gastric emptying and reduces caloric intake in research models, contributing to weight reduction studies
Research Insights
• Phase 2 trials in humans have shown significant body-weight reduction in obesity research models (up to ~24% over 48 weeks in highest dose groups)
• Explored for potential improvements in blood glucose, lipid profiles, and metabolic biomarkers
• Being investigated in combination or comparison studies with other peptides for enhanced efficacy in weight and metabolic research